Committed to the preservation of vision.
Help bring the first ophthalmic formulation of bevacizumab to people living with wet AMD.

Global Medical Lead

ABOUT OUTLOOK THERAPEUTICS

Outlook Therapeutics (Nasdaq: OTLK) is a commercial-stage biopharmaceutical company redefining the standard of care in retinal disease. In the United States, our lead product has received FDA approval, making it the first and only FDA-approved ophthalmic formulation of its kind for the treatment of wet AMD, and we are preparing for US commercial launch. Our lead product is also the first ophthalmic formulation of its kind to receive Marketing Authorization from the European Commission and the UK MHRA for the treatment of wet age-related macular degeneration (wet AMD), and has launched across Germany, Austria, and the UK. Driven by the stories of the patients we serve, we are united with the vision-care community around a single goal: a future where everyone with retinal disease can envision a brighter world.

THE OPPORTUNITY

Reports To – EVP, Clinical, Regulatory & Medical Affairs
Level – Senior Director
Location – Remote ( US-based) with global scope
Employment Type – Full-time
Direct Reports –Yes

This is a rare ground-floor moment at a company hitting its commercial inflection point. As a lean, fast-moving organization, we offer scope and ownership that larger companies can’t: your work is visible, your decisions matter, and you’ll help build the function rather than simply maintain it. You’ll partner directly with senior leadership and see a clear line between what you do and patients gaining access to a new treatment option.

This is a global medical leadership role: you serve as the company’s Medical Affairs Lead, holding medical and scientific accountability for the accuracy, integrity, and compliance of everything the organization says and does externally, while also collaborating across functions, keeping clinical, commercial, and market access strategy aligned as we prepare for US commercial launch.

WHAT YOU’LL DO

Medical Direction & Clinical Leadership

• Hold medical accountability as the organization’s Medical Director for retina practice patterns, and their clinical and commercial implications.
• Chair or co-chair medical review of scientific, promotional, and educational materials, serving as final medical/scientific sign-off authority.
• Provide clinical and scientific leadership to Medical Affairs on advisory board plans, evidence needs, and scientific content strategy.
• Own benefit-risk framing and ensure medical accuracy and consistency of all clinical claims across US and EU teams.
• Serve as a senior medical point of contact for cross-functional teams seeking clinical or scientific guidance.

Evidence Generation & Medical Governance

• Drive RWE strategy, technical review, and integration across Clinical, Regulatory, and Insights.
• Lead medical review and approval of investigator-initiated research (IIR) proposals in partnership with Medical Affairs and Clinical.
• Establish and uphold medical governance standards for scientific rigor, data interpretation, and evidence quality.
• Provide medical input into pharmacovigilance and safety-signal discussions in partnership with PV and Clinical Affairs.

Field Medical Excellence & Training

• Build and lead integrated training programs spanning Commercial, Medical, and Market Access teams, grounded in sound clinical and scientific principles.
• Translate clinical data and real-world insights into medically accurate, actionable direction for the field.
• Own medical-legal-regulatory (MLR) review of field-facing and promotional materials, applying clinical rigor to every asset.
• Mentor and provide medical guidance to field-facing medical and commercial personnel.

External Medical Engagement

• Cultivate peer-to-peer relationships with KOLs, retina specialists, and investigators, as the organization’s senior medical representative.
• Guide and provide medical sign-off on publications, scientific materials, and external educational content.
• Ensure all external scientific and commercial communication is medically accurate, aligned, and compliant.
• Represent Medical at scientific congresses and advisory engagements as needed.

Launch Preparation & Cross-Functional Alignment

• Partner with the commercial leadership on go-to-market readiness, field alignment, and external medical strategy.
• Advise payer and access teams on the clinical and scientific considerations tied to compounding.
• Contribute medical judgment to scenario planning, risk mitigation, and readiness milestones across functions.
• Collaborate with PV, Clinical Affairs, and Regulatory to maintain scientific and medical consistency through launch.

WHAT YOU’LL BRING

Required

• MD, PharmD, or PhD required; this is a Medical Director-level role with direct medical and scientific accountability.
• 10+ years in Medical Affairs, Clinical, Commercial Excellence, Market Access, or related disciplines, including direct experience holding medical sign-off or medical governance authority.
• Deep clinical/scientific expertise in retina practice patterns, and evidence-generation models.
• Demonstrated experience leading medical review (e.g., MLR) and providing medical/scientific sign-off on external materials.
• Experience training commercial, medical, and access teams on clinical and scientific content.
• Experience with RWE, IIRs, or evidence strategy in launch preparation.
• Strong cross-functional leadership and communication skills, with the credibility to represent Medical at the senior level.
• Ability to thrive in a lean, fast-moving environment.

Preferred

• Active medical licensure and/or board certification (e.g., ophthalmology, retina).
• Experience with pharmacovigilance or safety review processes.
• Global / international market experience.

WHAT WE OFFER

• Competitive base salary, annual performance bonus, and equity — so you share in the value you help create
• Comprehensive health coverage: medical, dental, and vision
• 401(k) with company match
• Generous paid time off and company holidays
• A high-trust, low-bureaucracy culture with direct access to leadership and real room to grow
• Mission-driven work that helps preserve sight for patients who are counting on it

COMPENSATION

In keeping with our commitment to pay transparency, the good-faith base salary range for this role is $215,000-$295,000, with an annual target bonus of 20-25%. This role is also eligible for a meaningful equity grant, reflecting the opportunity to build lasting value at a company at a commercial inflection point. Final compensation reflects experience, skills, and location.

OUR COMMITMENT

Outlook Therapeutics is an equal opportunity employer. We are committed to building an inclusive environment where every team member can do their best work, and we consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected by law.