What is AMD?
Age-related macular degeneration, AMD, is a common eye condition and a leading cause of vision loss among people age 50 and older. It causes damage to the macula, a small spot near the center of the retina and the part of the eye needed for sharp, central vision, which lets us see objects that are straight ahead.*
What is "Wet" AMD?
Wet AMD is a form of “late stage” AMD, and is also called neovascular AMD. In wet AMD, abnormal blood vessels grow underneath the retina. These vessels can leak fluid and blood, which may lead to swelling and damage of the macula, causing vision loss.*
What is VEGF?
With wet AMD, abnormally high levels of vascular endothelial growth factor (VEGF) are secreted in the eyes. VEGF is a protein that promotes the growth of new abnormal blood vessels. Anti-VEGF injection therapy blocks this growth.*
How Established is Anti-VEGF Therapy?
Since the advent of anti-VEGF therapy, it has become the standard-of-care treatment option within the retina community globally.
Retinal diseases, including wet AMD, diabetic retinopathy/diabetic macular edema, and retinal vein occlusion, are significant diseases worldwide, with a prevalence of 34.5 million patients in the United States, United Kingdom, top four European countries, Japan, China and Australia in 2020. In 2020, total revenue from FDA-approved anti-VEGFs is estimated to exceed $13.1 billion annually in those nine ophthalmic markets.**
Although not currently FDA-approved for use in treating wet AMD, unapproved repackaged intravenous (IV) bevacizumab from compounding pharmacies is believed to account for approximately 50% of all wet AMD prescriptions in the United States.